ICD-10 Code C81.30 – Lymphocyte depleted Hodgkin lymphoma, unspecified site (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C81.30 – Lymphocyte depleted Hodgkin lymphoma, unspecified site
What it is
C81.30 identifies lymphocyte-depleted Hodgkin lymphoma when the site is not specified. Use it for a Hodgkin lymphoma subtype with fewer lymphocytes and more abnormal Reed-Sternberg cells, documented without a more exact anatomic location.
Clinical signs
Clinical features vary; refer to documentation. Commonly reported findings in Hodgkin lymphoma include enlarged lymph nodes, unexplained weight loss, fever, night sweats, and fatigue, but the subtype and site must be confirmed in the record.
When to use this code
Use C81.30 when the provider documents lymphocyte-depleted Hodgkin lymphoma and does not specify the involved site. This is appropriate for finalized diagnoses, problem lists, and encounter notes that clearly name this subtype. If the site is later identified, code the documented location instead.
Do not use for
Do not use this code for other Hodgkin lymphoma subtypes, non-Hodgkin lymphoma, or unspecified lymphoma. Check documentation if the record only says “Hodgkin lymphoma” without the lymphocyte-depleted subtype.
Coding tip
Confirm both the subtype and the unspecified site wording before assigning C81.30.