ICD-10 Code C81.00 – Nodular lymphocyte predominant Hodgkin lymphoma, unspecified site (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C81.00 – Nodular lymphocyte predominant Hodgkin lymphoma, unspecified site
What it is
C81.00 identifies nodular lymphocyte predominant Hodgkin lymphoma when the provider does not document a specific lymph node region or other site. Use it for this distinct Hodgkin lymphoma subtype, not for generic Hodgkin disease.
Clinical signs
Clinical features vary; refer to documentation. Common findings include painless lymph node enlargement, often with an indolent course, and pathology confirming nodular lymphocyte predominant Hodgkin lymphoma.
When to use this code
Use C81.00 when the diagnosis is documented as nodular lymphocyte predominant Hodgkin lymphoma and the site is not specified. It also fits when the record confirms this subtype but does not name a nodal region or extranodal site. Check documentation if the site is later clarified.
Do not use for
Do not use this code for classical Hodgkin lymphoma or for other lymphoma subtypes. If the provider documents a specific site, use the more specific site code instead of unspecified site.
Coding tip
Code the lymphoma subtype exactly as documented and verify whether a site is named before assigning the unspecified site code.