ICD-10 Code C81.3 – Lymphocyte depleted Hodgkin lymphoma (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C81.3 – Lymphocyte depleted Hodgkin lymphoma
What it is
C81.3 identifies lymphocyte depleted Hodgkin lymphoma, a rare subtype of Hodgkin lymphoma. It refers to a malignant lymphoma with very few normal lymphocytes in the involved tissue.
Clinical signs
Findings may include enlarged lymph nodes, systemic “B” symptoms, or evidence of advanced disease. Clinical features vary; refer to documentation and pathology for confirmation.
When to use this code
Use this code when the medical record specifically documents lymphocyte depleted Hodgkin lymphoma. It may appear in oncology notes, pathology reports, discharge summaries, or problem lists.
Choose it only when the subtype is stated clearly. If the record says only “Hodgkin lymphoma” or another subtype, code the documented diagnosis instead.
Do not use for
Do not use C81.3 for unspecified Hodgkin lymphoma or for other Hodgkin subtypes. Check documentation if the pathology wording is incomplete or conflicting.
Coding tip
Confirm the exact histologic subtype in the pathology report before assigning C81.3.