ICD-10 Code F19.22 – Other psychoactive substance dependence with intoxication (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code F19.22 – Other psychoactive substance dependence with intoxication
What it is
F19.22 identifies dependence on a psychoactive substance other than alcohol, opioids, cannabis, or cocaine, with current intoxication. Use it when the record shows both dependence and intoxication from the same substance.
Clinical signs
Clinical features vary; refer to documentation. Intoxication may include impaired judgment, altered behavior, reduced coordination, or other substance-specific effects, along with evidence of dependence such as compulsive use or inability to cut down.
When to use this code
Use this code when the provider documents dependence on another psychoactive substance and states the patient is intoxicated at the same encounter. You should code the documented substance-related condition, not a nonspecific use history. Check documentation if the substance or relationship between dependence and intoxication is unclear.
Do not use for
Do not use this code for simple intoxication without dependence, or for dependence without intoxication. Do not assume it applies to a specific drug class unless the record supports that coding choice.
Coding tip
Verify the substance name and the provider’s wording for dependence and intoxication before assigning F19.22.