ICD-10 Code F19.21 – Other psychoactive substance dependence, in remission (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code F19.21 – Other psychoactive substance dependence, in remission
What it is
F19.21 identifies a past dependence on another psychoactive substance, with the dependence currently in remission. Use it when the disorder is no longer active, but the history remains clinically relevant.
Clinical signs
Clinical features vary; refer to documentation. Records may note prior compulsive use, tolerance, withdrawal, or loss of control, followed by a documented period of remission without current dependence symptoms.
When to use this code
Use this code when the provider documents dependence on a psychoactive substance other than alcohol, opioids, or tobacco, and states that it is in remission. It fits follow-up visits, problem lists, and histories where the condition still affects care planning. Check documentation for the specific substance and remission status.
Do not use for
Do not use F19.21 if dependence is active or if the record only shows use, abuse, or intoxication. Also avoid it when the substance category is better captured by a more specific code.
Coding tip
Confirm both the substance class and the word “in remission” in the provider note before assigning F19.21.