ICD-10 Code E88.0 – Disorders of plasma-protein metabolism, not elsewhere classified (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E88.0 – Disorders of plasma-protein metabolism, not elsewhere classified
What it is
E88.0 identifies disorders of plasma-protein metabolism that do not fit a more specific ICD-10-CM category. Use it for documented abnormalities in plasma proteins when the record does not name a clearer diagnosis.
Clinical signs
Clinical features vary; refer to documentation. Findings may include abnormal serum protein patterns, protein deficiency, or other nonspecific signs tied to altered plasma-protein handling.
When to use this code
Use E88.0 when the provider documents a plasma-protein metabolism disorder and does not specify a more exact condition. It is appropriate when the chart describes a nonspecific protein abnormality rather than a defined inherited or acquired disease. Check documentation if the diagnosis is incomplete.
Do not use for
Do not use this code for clearly named plasma protein disorders with their own ICD-10-CM code. Avoid it when the record only shows a laboratory abnormality without a documented disorder.
Coding tip
Code E88.0 only after confirming the provider has diagnosed a plasma-protein metabolism disorder, not just an isolated abnormal test result.