ICD-10 Code E88.12 – Generalized lipodystrophy (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E88.12 – Generalized lipodystrophy
What it is
E88.12 identifies generalized lipodystrophy, a rare disorder marked by near-total loss of body fat. You use it when documentation states generalized or congenital/acquired generalized lipodystrophy.
Clinical signs
Patients may show marked absence of subcutaneous fat, muscular appearance, and metabolic complications such as insulin resistance. Clinical features vary; refer to documentation.
When to use this code
Use E88.12 when the provider documents generalized lipodystrophy as the diagnosis, including congenital or acquired forms if specifically described as generalized. Code it for confirmed encounters, specialty evaluations, or follow-up visits documenting the condition. Check documentation if the record only mentions lipodystrophy without specifying generalized.
Do not use for
Do not use this code for localized or partial lipodystrophy, or for simple weight loss without a documented lipodystrophy diagnosis. Check documentation when the chart is nonspecific.
Coding tip
Confirm the documentation says “generalized” lipodystrophy before assigning E88.12.