ICD-10 Code E85.81 – Light chain (AL) amyloidosis (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E85.81 – Light chain (AL) amyloidosis
What it is
E85.81 identifies light chain (AL) amyloidosis, a disorder in which abnormal immunoglobulin light chains form amyloid deposits in tissues. These deposits can impair organ function and may involve the heart, kidneys, nerves, or other sites.
Clinical signs
Clinical features vary; refer to documentation. Common findings may include proteinuria, cardiomyopathy, neuropathy, hepatomegaly, or unexplained weight loss when AL amyloidosis affects multiple organs.
When to use this code
Use E85.81 when the provider documents AL amyloidosis, light chain amyloidosis, or primary amyloidosis due to monoclonal light chain deposition. Code it when the diagnosis is confirmed or clearly established in the record. If the note only mentions suspected amyloidosis, check documentation before assigning the code.
Do not use for
Do not use this code for other amyloidosis types, such as hereditary or secondary forms, unless the record specifically supports AL amyloidosis. Do not assign it for nonspecific amyloid findings without a documented diagnosis.
Coding tip
Review the pathology, hematology, or specialist note to confirm the amyloidosis type before coding E85.81.