ICD-10 Code E85.8 – Other amyloidosis (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E85.8 – Other amyloidosis
What it is
Use this code for amyloidosis that is documented but does not fit a more specific type. It indicates abnormal amyloid protein deposits in tissues, with the exact subtype not otherwise classified.
Clinical signs
Clinical features vary; refer to documentation. Amyloidosis may present with organ dysfunction, such as heart, kidney, nerve, or liver involvement, but the record must support the diagnosis and type.
When to use this code
Assign E85.8 when the provider documents “other amyloidosis,” “amyloidosis NOS,” or a similar nonspecific form that is not indexed to a more specific code. Use it only when the subtype is confirmed or clearly stated in the note. If the record names a specific amyloid type, code that specific option instead.
Do not use for
Do not use this code when the documentation identifies a more specific amyloidosis category. If the diagnosis is only suspected or the record is unclear, check documentation before coding.
Coding tip
Code the most specific amyloidosis type documented; if the note only says “other” or “unspecified,” E85.8 is the appropriate choice.