ICD-10 Code E85.4 – Organ-limited amyloidosis (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E85.4 – Organ-limited amyloidosis
What it is
Organ-limited amyloidosis means abnormal amyloid protein deposits are confined to one organ or tissue rather than widespread throughout the body. Use this code when documentation specifies a localized amyloid process.
Clinical signs
Clinical features vary by the organ involved and may include mass-like tissue changes, organ dysfunction, or incidental biopsy findings. Confirm the diagnosis with documentation showing amyloid limited to a single site.
When to use this code
Use E85.4 when the provider documents amyloidosis affecting only one organ or one localized area, such as a single tissue or organ biopsy result. It is appropriate when the record clearly distinguishes the condition from systemic amyloidosis. If the site or extent is unclear, check documentation.
Do not use for
Do not use this code for systemic amyloidosis or when the record does not specify organ-limited disease. Avoid it if the diagnosis is uncertain or if another amyloidosis type is documented.
Coding tip
Code E85.4 only when the chart explicitly states localized or organ-limited amyloidosis; otherwise, verify the provider’s wording.