ICD-10 Code E85.3 – Secondary systemic amyloidosis (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E85.3 – Secondary systemic amyloidosis
What it is
Use this code for systemic amyloidosis that develops as a result of another underlying condition. The amyloid deposits affect multiple organs and are documented as secondary rather than primary or hereditary.
Clinical signs
Clinical features vary; refer to documentation. Common findings may include organ dysfunction from amyloid deposition, such as renal, cardiac, gastrointestinal, or neurologic involvement.
When to use this code
Assign E85.3 when the record clearly states secondary systemic amyloidosis or amyloidosis due to another disease process. Use it for confirmed systemic involvement, not for a nonspecific amyloid finding alone.
If the provider links amyloidosis to an underlying chronic condition, code the documented cause as well when instructed by the record. Check documentation for the exact type and relationship.
Do not use for
Do not use this code for localized amyloidosis, hereditary forms, or amyloidosis without systemic involvement. Do not guess the type if the documentation does not specify secondary systemic disease.
Coding tip
Verify that the provider documents both systemic amyloidosis and its secondary nature before assigning E85.3.