ICD-10 Code E85.2 – Heredofamilial amyloidosis, unspecified (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E85.2 – Heredofamilial amyloidosis, unspecified
What it is
E85.2 identifies inherited amyloidosis when the specific hereditary type is not documented. It indicates a familial disorder in which abnormal amyloid protein deposits build up in tissues.
Clinical signs
Clinical features vary; refer to documentation. Commonly reported findings include progressive organ dysfunction, neuropathy, cardiomyopathy, or renal involvement, but the exact pattern depends on the hereditary form.
When to use this code
Use E85.2 when the record states heredofamilial or familial amyloidosis and does not name a more specific subtype. It is appropriate when the clinician documents inherited amyloid disease without further detail. If the subtype is identified, code the specific condition instead.
Do not use for
Do not use this code for nonfamilial or secondary amyloidosis. Also avoid it when the documentation specifies a different hereditary amyloidosis type; check documentation.
Coding tip
Confirm whether the provider documented a specific hereditary subtype before defaulting to E85.2.