ICD-10 Code E27.49 – Other adrenocortical insufficiency (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E27.49 – Other adrenocortical insufficiency
What it is
E27.49 identifies adrenal cortex insufficiency that does not fit a more specific ICD-10 category. It means the adrenal glands are not making enough corticosteroid hormones, but the cause is documented as other or unspecified within this group.
Clinical signs
Clinical features vary; refer to documentation. Common findings in adrenal insufficiency may include fatigue, weakness, weight loss, low blood pressure, or poor stress tolerance, but you should code from the documented diagnosis rather than symptoms alone.
When to use this code
Use E27.49 when the clinician documents adrenocortical insufficiency and the record does not support a more specific code such as primary or secondary adrenal insufficiency. It is appropriate for charted “other” adrenal insufficiency, including cases with incomplete detail. Check documentation if the cause is unclear.
Do not use for
Do not use this code for Addison disease, secondary adrenal insufficiency, or adrenal crisis when those are specifically documented. Also avoid it when the chart only mentions nonspecific fatigue or hypotension without a confirmed diagnosis.
Coding tip
Code the most specific adrenal insufficiency diagnosis documented, and query for clarification if the record only says “adrenal insufficiency.”