ICD-10 Code E27.4 – Other and unspecified adrenocortical insufficiency (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E27.4 – Other and unspecified adrenocortical insufficiency
What it is
E27.4 identifies adrenocortical insufficiency when the chart does not specify a more exact type. It covers reduced adrenal cortex function, but not cases already classified as primary, secondary, or drug-induced if documented elsewhere.
Clinical signs
Clinical features vary; refer to documentation. Commonly noted findings may include fatigue, weakness, weight loss, low blood pressure, or nonspecific symptoms of adrenal hormone deficiency.
When to use this code
Use E27.4 when the provider documents adrenocortical insufficiency but does not identify the cause or subtype. It also fits “unspecified adrenal insufficiency” when no further detail is available in the record. If the note later clarifies etiology, code the more specific diagnosis instead.
Do not use for
Do not use this code for Addison disease, secondary adrenal insufficiency, or corticosteroid-induced adrenal suppression when those are documented. Check documentation if the chart names a different adrenal disorder.
Coding tip
Query for the underlying cause whenever the record only says “adrenal insufficiency.”