ICD-10 Code L27.0 – Generalized skin eruption due to drugs and medicaments taken internally (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code L27.0 – Generalized skin eruption due to drugs and medicaments taken internally
What it is
L27.0 identifies a generalized skin eruption caused by a drug or medicament taken internally. Use it when the rash is believed to be a systemic medication reaction rather than a localized contact exposure.
Clinical signs
Typical findings include a widespread rash, often with redness, macules, papules, or itching. Clinical features vary; refer to documentation for the specific drug reaction pattern and severity.
When to use this code
Use L27.0 when the record documents a generalized eruption attributed to an internally taken medication, such as an oral, injectable, or other systemic drug. Code it when the clinician links the rash to the medication exposure. If the note only says “rash” without a drug cause, check documentation.
Do not use for
Do not use this code for localized contact dermatitis, simple drug intolerance, or adverse effects documented elsewhere without a generalized rash. If the eruption is not attributed to an internal medication, choose the documented condition.
Coding tip
Look for explicit provider wording connecting the generalized rash to a systemic drug before assigning L27.0.