ICD-10 Code F19.921 – Other psychoactive substance use, unspecified with intoxication with delirium (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code F19.921 – Other psychoactive substance use, unspecified with intoxication with delirium
What it is
This code identifies intoxication from an unspecified psychoactive substance that is accompanied by delirium. Use it when the substance is known only as “other psychoactive,” and the record documents delirium during intoxication.
Clinical signs
Delirium typically presents with acute confusion, reduced awareness, disorganized thinking, and fluctuating attention. Clinical features vary; refer to documentation for the specific mental status findings tied to intoxication.
When to use this code
Use this code when the provider documents intoxication from an unspecified psychoactive substance and explicitly links it to delirium. It fits cases where the exact drug is not named, but the intoxication state and delirium are both documented. If the record does not clearly support delirium, check documentation.
Do not use for
Do not use this code for substance use without intoxication, or for intoxication without delirium. Do not assign it when the substance is identified more specifically and a different code applies.
Coding tip
Confirm that both intoxication and delirium are documented; if either element is unclear, query the provider.