ICD-10 Code F19.281 – Other psychoactive substance dependence with psychoactive substance-induced sexual dysfunction (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code F19.281 – Other psychoactive substance dependence with psychoactive substance-induced sexual dysfunction
What it is
This code identifies dependence on another psychoactive substance when the substance causes sexual dysfunction. Use it when both the substance use disorder and the induced sexual problem are documented.
Clinical signs
Clinical features vary; refer to documentation. You may see dependence behaviors plus decreased sexual desire, arousal, or performance linked to the substance’s effects.
When to use this code
Use this code when the provider documents dependence on a psychoactive substance other than alcohol, tobacco, or opioids, and specifically links sexual dysfunction to that substance. The record should show a causal relationship, not just coexisting problems. Check documentation if the substance or dysfunction is not clearly identified.
Do not use for
Do not use this code for sexual dysfunction without documented substance-induced causation. Also avoid it when the substance use is not dependence or when a more specific substance-related code is documented.
Coding tip
Code the dependence and the induced sexual dysfunction together only when the provider explicitly connects them.