ICD-10 Code F19.259 – Other psychoactive substance dependence with psychoactive substance-induced psychotic disorder, unspecified (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code F19.259 – Other psychoactive substance dependence with psychoactive substance-induced psychotic disorder, unspecified
What it is
This code identifies dependence on another psychoactive substance together with a psychotic disorder caused by that substance, when the psychosis is not further specified. Use it when documentation links both conditions.
Clinical signs
Clinical features vary; refer to documentation. Common psychotic features may include hallucinations, delusions, or disorganized thinking occurring in the setting of psychoactive substance dependence.
When to use this code
Use F19.259 when the provider documents dependence on a non-alcohol, non-opioid, non-cocaine, or similarly classified psychoactive substance and a substance-induced psychotic disorder. The record should support both the dependence and the psychotic disorder, but the psychosis is not otherwise specified. If the substance or psychotic presentation is unclear, check documentation.
Do not use for
Do not use this code for psychosis unrelated to substance use, or for substance dependence without a documented psychotic disorder. If the substance class or diagnosis details are different, choose the more specific code supported by documentation.
Coding tip
Confirm that the provider links the psychosis to the substance and that “unspecified” is truly documented before assigning F19.259.