ICD-10 Code F11.22 – Opioid dependence with intoxication (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code F11.22 – Opioid dependence with intoxication
What it is
F11.22 identifies opioid dependence when the patient is also intoxicated. Use it when documentation shows both ongoing opioid dependence and current opioid intoxication.
Clinical signs
Clinical features vary; refer to documentation. Intoxication may include drowsiness, slowed thinking, reduced coordination, or respiratory depression, along with evidence of opioid dependence.
When to use this code
Use this code when the record clearly states opioid dependence with intoxication, such as a visit for altered mental status in a patient documented as opioid dependent and currently intoxicated. It may also apply when the provider links observed intoxication to opioid use disorder. Check documentation for the specific opioid and any associated substance use details.
Do not use for
Do not use this code for opioid dependence without intoxication, opioid poisoning, or simple opioid use. If the note does not confirm intoxication, check documentation before assigning F11.22.
Coding tip
Code the dependence and intoxication only when both are documented by the provider.