ICD-10 Code F11.21 – Opioid dependence, in remission (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code F11.21 – Opioid dependence, in remission
What it is
This code identifies a documented opioid dependence that is no longer active and is described as being in remission. Use it when the record shows prior dependence, but current dependence criteria are not being met.
Clinical signs
Clinical features vary; refer to documentation. Typical records may note a history of opioid dependence with sustained remission, absence of current compulsive use, and no active withdrawal or intoxication findings.
When to use this code
Use this code when the provider specifically documents opioid dependence in remission, such as “opioid use disorder, in remission” or similar wording tied to dependence. It is appropriate for patients with a prior dependence history who are not currently meeting active dependence criteria. Check documentation if the note only says “history of opioid use” without remission status.
Do not use for
Do not use this code for active opioid dependence, opioid abuse, or simple past use without remission. If the chart does not clearly state remission, check documentation before assigning F11.21.
Coding tip
Code the remission status only when the provider documents it explicitly; otherwise, query or code the documented active condition.