ICD-10 Code E88.3 – Tumor lysis syndrome (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E88.3 – Tumor lysis syndrome
What it is
Tumor lysis syndrome is a metabolic complication that happens when many cancer cells break down quickly and release their contents into the bloodstream. You use this code for the syndrome itself, not for the underlying malignancy.
Clinical signs
Clinical features vary; refer to documentation. Commonly documented findings include acute metabolic abnormalities and possible kidney involvement after rapid tumor cell breakdown.
When to use this code
Use E88.3 when the record clearly states tumor lysis syndrome, whether spontaneous or after cancer therapy. Code it when the provider documents the syndrome as a diagnosis or complication requiring assessment. Check documentation for the associated cancer and any related conditions.
Do not use for
Do not use this code for the underlying malignancy alone, without tumor lysis syndrome. Do not assign it for nonspecific electrolyte abnormalities unless the provider links them to tumor lysis syndrome.
Coding tip
Confirm the provider names tumor lysis syndrome explicitly and code the underlying cancer separately when documented.