ICD-10 Code E72.51 – Non-ketotic hyperglycinemia (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E72.51 – Non-ketotic hyperglycinemia
What it is
Non-ketotic hyperglycinemia is an inherited metabolic disorder in which glycine builds up in the body, especially the brain. Use this code for the diagnosed condition, not for a nonspecific abnormal laboratory finding.
Clinical signs
Clinical features vary; refer to documentation. Standard references describe neonatal or early-infantile neurologic symptoms such as lethargy, poor feeding, hypotonia, seizures, and developmental impairment.
When to use this code
Use E72.51 when the provider documents non-ketotic hyperglycinemia, glycine encephalopathy, or a confirmed inborn error of glycine metabolism. It also fits follow-up encounters for a known diagnosis. If the record only mentions elevated glycine without confirmation, check documentation before coding.
Do not use for
Do not use this code for ketotic hyperglycinemia or for isolated hyperglycinemia without a confirmed diagnosis. Also avoid it when the chart is unclear and the condition is only being considered.
Coding tip
Code the documented metabolic disorder name exactly as recorded, and verify whether the provider has confirmed the diagnosis or only noted a workup.