ICD-10 Code E72.50 – Disorder of Glycine Metabolism, Unspecified (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E72.50 – Disorder of glycine metabolism, unspecified
What it is
E72.50 identifies a disorder affecting glycine metabolism when the specific type is not documented. Use it for an inherited or acquired metabolic problem involving glycine, but only when the record does not name a more specific diagnosis.
Clinical signs
Clinical features vary; refer to documentation. Records may describe developmental delay, neurologic abnormalities, or other findings consistent with an inborn error of metabolism, but the exact presentation depends on the underlying disorder.
When to use this code
Use this code when the clinician documents a disorder of glycine metabolism and does not specify the subtype. It is also appropriate when the chart confirms a glycine-related metabolic condition but lacks enough detail for a more precise code. Review the note for any named syndrome or alternate metabolic diagnosis before assigning E72.50.
Do not use for
Do not use this code for hyperglycinemia or other glycine disorders that are specifically documented and have a more exact code. Check documentation if the condition is actually another amino acid or organic acid metabolism disorder.
Coding tip
Query the provider when the record says only “glycine disorder” or “metabolic abnormality” and the exact diagnosis is unclear.