ICD-10 Code E72.3 – Disorders of lysine and hydroxylysine metabolism (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E72.3 – Disorders of lysine and hydroxylysine metabolism
What it is
E72.3 identifies inherited disorders that affect the body’s ability to break down lysine and hydroxylysine. These are rare metabolic conditions and usually require specialist evaluation.
Clinical signs
Clinical features vary; refer to documentation. Findings may include developmental delay, neurologic symptoms, or other signs of an inborn error of metabolism, depending on the specific disorder.
When to use this code
Use E72.3 when the provider documents a disorder of lysine or hydroxylysine metabolism, such as a confirmed inherited metabolic defect. It is appropriate for genetic, biochemical, or specialist diagnoses tied to this category. If the record only suggests a possible metabolic problem, check documentation before coding.
Do not use for
Do not use this code for nonspecific amino acid abnormalities without a documented lysine or hydroxylysine disorder. Do not assign it when the chart only mentions screening, family history, or an unrelated metabolic condition.
Coding tip
Code from the documented diagnosis, not from isolated test results or suspicion alone.