ICD-10 Code E72.29 – Other disorders of urea cycle metabolism (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E72.29 – Other disorders of urea cycle metabolism
What it is
E72.29 identifies a urea cycle metabolism disorder that does not fit a more specific code. These inherited conditions impair the body’s ability to remove ammonia, so you should use this code when documentation says “other” urea cycle disorder.
Clinical signs
Clinical features vary; refer to documentation. Commonly reported findings include recurrent hyperammonemia, vomiting, lethargy, poor feeding, confusion, or neurologic changes, especially during illness or fasting.
When to use this code
Use E72.29 when the record documents a urea cycle disorder but names an atypical, unspecified, or nonlisted type. It also fits confirmed inherited metabolic disease when the provider states “other urea cycle metabolism disorder.” If the chart names a specific urea cycle defect, code that condition instead.
Do not use for
Do not use this code for hyperammonemia without a documented urea cycle disorder. Do not assign it when the record identifies a more specific metabolic diagnosis or when documentation is insufficient; check documentation.
Coding tip
Look for the provider’s exact wording and code the most specific urea cycle diagnosis documented.