ICD-10 Code E34.321 – Primary insulin-like growth factor-1 (IGF-1) deficiency (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E34.321 – Primary insulin-like growth factor-1 (IGF-1) deficiency
What it is
E34.321 identifies primary IGF-1 deficiency, a rare endocrine disorder in which the body does not produce enough insulin-like growth factor-1 despite appropriate growth hormone signaling. Use it when documentation specifically states primary IGF-1 deficiency.
Clinical signs
Typical findings include poor linear growth, short stature, and delayed growth velocity in childhood. Clinical features vary; refer to documentation for the specific diagnostic basis, such as endocrine evaluation or specialist assessment.
When to use this code
Use this code when the provider documents primary IGF-1 deficiency as the diagnosed condition. It may also apply when the record clearly links growth failure to this specific deficiency rather than to generalized growth hormone deficiency or another endocrine cause. Check documentation if the wording is unclear.
Do not use for
Do not use this code for isolated short stature, nonspecific growth delay, or growth hormone deficiency without documented primary IGF-1 deficiency. If the chart only says “low IGF-1” without a diagnosis, check documentation.
Coding tip
Code E34.321 only when the diagnosis is explicit; otherwise, query for confirmation of primary IGF-1 deficiency.