ICD-10 Code E34.322 – Insulin-like growth factor-1 (IGF-1) resistance (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E34.322 – Insulin-like growth factor-1 (IGF-1) resistance
What it is
IGF-1 resistance means the body does not respond normally to insulin-like growth factor-1, a hormone involved in growth and development. You use this code for documented resistance to IGF-1, not for general growth concerns.
Clinical signs
Clinical features vary; refer to documentation. Commonly, records may note impaired growth response, short stature, or other findings linked to reduced IGF-1 activity, but the diagnosis should be explicitly stated.
When to use this code
Use E34.322 when the clinician documents IGF-1 resistance as the diagnosed condition. It may appear in endocrine evaluations, genetic workups, or specialty notes describing abnormal response to IGF-1.
Code it when the chart clearly identifies resistance rather than low IGF-1 production or another growth disorder. If the note is vague, check documentation before assigning the code.
Do not use for
Do not use this code for isolated short stature, delayed growth, or low IGF-1 levels without documented resistance. Check documentation if the record describes a different endocrine disorder.
Coding tip
Confirm the exact wording in the assessment or problem list; “IGF-1 resistance” must be stated or clearly supported before you code E34.322.