ICD-10 Code C15.5 – Malignant neoplasm of lower third of esophagus (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C15.5 – Malignant neoplasm of lower third of esophagus
What it is
C15.5 identifies a malignant tumor arising in the lower third of the esophagus. Use it when the record documents cancer in the distal esophagus, not the gastroesophageal junction unless that site is specifically stated.
Clinical signs
Typical findings include progressive dysphagia, weight loss, and odynophagia. Endoscopy, biopsy, or imaging usually confirms the diagnosis; clinical features vary, so refer to documentation.
When to use this code
Assign this code when the provider documents primary esophageal cancer in the lower third of the esophagus. It may also apply after pathology or imaging localizes the malignancy to the distal esophagus. If the note only says “esophageal cancer” without location, check documentation.
Do not use for
Do not use C15.5 for malignancy of the gastroesophageal junction, stomach, or middle/upper esophagus. If the primary site is unclear or another site is documented, check documentation.
Coding tip
Verify the exact anatomic site in the pathology or operative report before assigning C15.5.