ICD-10 Code E16 – Other disorders of pancreatic internal secretion (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E16 – Other disorders of pancreatic internal secretion
What it is
E16 is a category for disorders involving abnormal internal hormone secretion from the pancreas, especially when the condition does not fit a more specific diagnosis. Use it for pancreatic endocrine problems that are documented but not otherwise classified.
Clinical signs
Clinical features vary; refer to documentation. Findings may reflect hormone overproduction or deficiency, with symptoms such as recurrent hypoglycemia, autonomic symptoms, or other endocrine abnormalities depending on the underlying disorder.
When to use this code
Use E16 when the record clearly documents a pancreatic internal secretion disorder and no more specific ICD-10-CM code applies. It is appropriate when the provider identifies a pancreatic endocrine abnormality but does not name a specific tumor, syndrome, or other defined condition.
If the documentation is vague, confirm whether the issue is pancreatic, endocrine, or another metabolic disorder before coding. Check documentation when the chart only mentions abnormal glucose, hypoglycemia, or pancreatic disease without a clear endocrine diagnosis.
Do not use for
Do not use E16 for diabetes mellitus, exocrine pancreatic disease, or nonspecific abnormal laboratory findings. If the diagnosis is more specific, code that condition instead.
Coding tip
Code the documented pancreatic endocrine disorder only after confirming that no more specific diagnosis is supported in the record.