ICD-10 Code E16.4 – Increased secretion of gastrin (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E16.4 – Increased secretion of gastrin
What it is
E16.4 identifies increased gastrin secretion, a condition where the stomach hormone gastrin is produced in excess. It is used when documentation supports hypergastrinemia or a gastrin-secreting disorder.
Clinical signs
Clinical features vary; refer to documentation. Patients may have evidence of excess acid production, recurrent peptic ulcer disease, or other findings linked to elevated gastrin levels.
When to use this code
Use E16.4 when the provider documents increased gastrin secretion, hypergastrinemia, or a gastrin-secreting condition. Code it when the diagnosis is established and not just suspected. If the record only mentions abnormal testing without a diagnosis, check documentation.
Do not use for
Do not use this code for nonspecific abdominal pain, routine dyspepsia, or peptic ulcer disease without documented increased gastrin secretion. Do not assign it for suspected gastrinoma unless confirmed in the chart.
Coding tip
Look for explicit provider wording such as “hypergastrinemia” or “increased gastrin secretion” before assigning E16.4.