ICD-10 Code D82.4 – Hyperimmunoglobulin E [IgE] syndrome (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D82.4 – Hyperimmunoglobulin E [IgE] syndrome
What it is
D82.4 identifies Hyperimmunoglobulin E [IgE] syndrome, a rare primary immunodeficiency. It is used when documentation describes this inherited disorder with elevated IgE and recurrent infections.
Clinical signs
Clinical features often include recurrent skin and lung infections, eczema, and other immune dysfunction findings. Clinical features vary; refer to documentation.
When to use this code
Use D82.4 when the provider documents Hyperimmunoglobulin E syndrome, Job syndrome, or a confirmed IgE-related immunodeficiency. Apply it for encounters focused on the disorder itself or when it is the relevant chronic diagnosis being managed.
Do not use for
Do not use this code for isolated high IgE levels without a diagnosed syndrome. Do not assign it when the record only mentions eczema, recurrent infection, or immunodeficiency without confirmation. Check documentation.
Coding tip
Verify the exact syndrome name in the note; if the diagnosis is not explicit, query the provider before coding.