ICD-10 Code D80 – Immunodeficiency with predominantly antibody defects (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D80 – Immunodeficiency with predominantly antibody defects
What it is
D80 identifies primary immunodeficiency disorders where antibody production is mainly impaired. These conditions reduce the body’s ability to fight certain infections, especially those caused by bacteria.
Clinical signs
Clinical features vary; refer to documentation. Commonly documented findings include recurrent sinopulmonary infections, poor response to routine infections, and evidence of low or absent immunoglobulin production.
When to use this code
Use D80 when the provider documents a diagnosis of immunodeficiency with predominantly antibody defects or a specific disorder in this category. Apply it for confirmed primary antibody deficiency, not for a vague history of frequent infections alone. Check documentation if the record does not clearly identify the immune disorder.
Do not use for
Do not use D80 for secondary immunodeficiency, such as medication-related or disease-related immune suppression. Do not assign it when the chart only notes infection susceptibility without a documented antibody defect.
Coding tip
Match the code to the exact provider-documented immune disorder and verify whether the record supports a primary antibody defect.