ICD-10 Code D80.1 – Nonfamilial hypogammaglobulinemia (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D80.1 – Nonfamilial hypogammaglobulinemia
What it is
D80.1 identifies low gamma globulin levels that are not due to a familial or inherited immune disorder. Use it for acquired or unspecified hypogammaglobulinemia when the record supports reduced immunoglobulins.
Clinical signs
Patients often have recurrent sinopulmonary or other bacterial infections, and may show poor antibody response. Clinical features vary; refer to documentation.
When to use this code
Use D80.1 when the provider documents nonfamilial hypogammaglobulinemia, acquired hypogammaglobulinemia, or low immunoglobulin levels without a hereditary cause. It may also fit follow-up visits for an established diagnosis. Check documentation if the note only says “immune deficiency” or “low globulins.”
Do not use for
Do not use this code for familial or congenital hypogammaglobulinemia, or when a more specific immune deficiency is documented. If the cause is unclear, check documentation.
Coding tip
Confirm that the chart distinguishes nonfamilial hypogammaglobulinemia from inherited antibody disorders before assigning D80.1.