ICD-10 Code D68.61 – Antiphospholipid syndrome (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D68.61 – Antiphospholipid syndrome
What it is
Antiphospholipid syndrome is an autoimmune clotting disorder in which the body makes antibodies that increase the risk of abnormal blood clots. It may also be linked to certain pregnancy complications.
Clinical signs
Clinical features vary; refer to documentation. Common findings include venous or arterial thrombosis and recurrent pregnancy loss, with diagnosis supported by persistent antiphospholipid antibodies and compatible clinical history.
When to use this code
Use D68.61 when the provider documents antiphospholipid syndrome, including primary or secondary disease, and the record supports the diagnosis. Code it for encounters focused on clotting risk, prior thrombosis, or pregnancy-related complications tied to this condition.
Do not assign it for a positive antibody test alone without documented syndrome. If the note only says antiphospholipid antibodies or lupus anticoagulant, check documentation before coding.
Do not use for
Do not use this code for nonspecific hypercoagulable states, thrombosis without antiphospholipid syndrome, or isolated laboratory positivity. Check documentation when the diagnosis is uncertain.
Coding tip
Code D68.61 only when the provider clearly documents antiphospholipid syndrome, not just antibody presence or suspected clotting disorder.