ICD-10 Code D68.52 – Prothrombin gene mutation (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D68.52 – Prothrombin gene mutation
What it is
D68.52 identifies a hereditary prothrombotic disorder caused by a prothrombin gene mutation. Use it when documentation states the patient has this genetic clotting tendency.
Clinical signs
Clinical features vary; refer to documentation. Patients may have a personal or family history of venous thromboembolism, recurrent clotting events, or known inherited thrombophilia.
When to use this code
Use D68.52 when the record specifically documents prothrombin gene mutation, prothrombin-related thrombophilia, or a confirmed inherited clotting disorder. It may support coding for genetic risk assessment or evaluation after thrombosis. Code the mutation only when it is established in the chart, not merely suspected.
Do not use for
Do not use this code for general hypercoagulable states without documentation of a prothrombin mutation. Check documentation if the note only mentions a history of blood clots or thrombophilia.
Coding tip
Verify that the provider names the prothrombin mutation explicitly before assigning D68.52.