ICD-10 Code D55.8 – Other anemias due to enzyme disorders (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D55.8 – Other anemias due to enzyme disorders
What it is
D55.8 identifies anemias caused by an inherited or acquired enzyme disorder affecting red blood cell survival. Use it when the record states an enzyme-related anemia that does not fit a more specific D55 category.
Clinical signs
Clinical features vary; refer to documentation. Typical findings may include anemia with evidence of red cell breakdown or reduced red cell lifespan, but you should code only what is documented.
When to use this code
Use D55.8 when the clinician documents “other anemia due to enzyme disorder,” “enzyme deficiency anemia,” or another specified enzyme-related anemia without a more precise code. It is appropriate when the chart supports the diagnosis and no specific enzyme disorder code applies. Check documentation if the cause is unclear.
Do not use for
Do not use this code for anemias with a different documented cause, such as blood loss, iron deficiency, or vitamin deficiency. Also avoid it when a more specific enzyme-disorder anemia code is documented.
Coding tip
Code the documented enzyme-related etiology first, and use D55.8 only when the record supports “other” rather than a more specific diagnosis.