ICD-10 Code D55 – Anemia due to enzyme disorders (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D55 – Anemia due to enzyme disorders
What it is
D55 identifies anemia caused by inherited or acquired enzyme defects that impair red blood cell survival. Use it when the record links the anemia to an enzyme disorder rather than another cause.
Clinical signs
Clinical features vary; refer to documentation. Typical findings include anemia with evidence of red blood cell breakdown, and the chart may note an enzyme deficiency such as a glucose-6-phosphate dehydrogenase disorder.
When to use this code
Use D55 when the provider documents anemia due to a specific enzyme disorder or clearly attributes the anemia to enzyme-related red cell fragility. It also fits cases where the disorder is the stated cause of hemolysis and anemia. If the record names a more specific subtype, code that more specific diagnosis.
Do not use for
Do not use D55 for anemia from blood loss, iron deficiency, vitamin deficiency, or chronic disease. Check documentation if the cause is unclear or if the enzyme disorder is not confirmed.
Coding tip
Code the documented enzyme disorder and the anemia only when the provider connects them explicitly.