ICD-10 Code C81.20 – Mixed cellularity Hodgkin lymphoma, unspecified site (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C81.20 – Mixed cellularity Hodgkin lymphoma, unspecified site
What it is
C81.20 identifies mixed cellularity Hodgkin lymphoma when the site is not specified. Use it for a confirmed Hodgkin lymphoma subtype with no documented anatomic location.
Clinical signs
Common findings include painless lymph node enlargement, fever, night sweats, and weight loss. Clinical features vary; refer to documentation for the confirmed subtype and any recorded site.
When to use this code
Use this code when the provider documents mixed cellularity Hodgkin lymphoma and does not name a specific site. It also fits when the record confirms the diagnosis, but the anatomic location is unavailable or not stated. Do not infer a site from imaging alone unless the diagnosis is clearly documented.
Do not use for
Do not use C81.20 for other Hodgkin lymphoma subtypes or for non-Hodgkin lymphomas. If the site is documented elsewhere in the record, code the more specific site-based option instead.
Coding tip
Check the pathology or oncology note first; if the subtype is mixed cellularity and the site is unspecified, C81.20 is the correct choice.