ICD-10 Code C92.22 – Atypical chronic myeloid leukemia, BCR/ABL-negative, in relapse (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C92.22 – Atypical chronic myeloid leukemia, BCR/ABL-negative, in relapse
What it is
This code identifies atypical chronic myeloid leukemia, BCR/ABL-negative, that has returned after a prior response or remission. It signals recurrent disease rather than a new diagnosis.
Clinical signs
Clinical features vary; refer to documentation. You may see recurrent leukemia findings such as worsening cytopenias, leukocytosis, splenomegaly, or other evidence that the disease has reappeared.
When to use this code
Use this code when the record clearly states atypical chronic myeloid leukemia, BCR/ABL-negative, and documents relapse or recurrent disease. It applies only when the provider indicates the condition is in relapse, not merely active or persistent.
If the chart does not specify relapse, check documentation before assigning C92.22. Code the most specific leukemia diagnosis available from the provider’s note.
Do not use for
Do not use this code for chronic myeloid leukemia with BCR/ABL positivity or for atypical chronic myeloid leukemia without relapse documentation. Check documentation if the recurrence status is unclear.
Coding tip
Verify both the atypical, BCR/ABL-negative subtype and the relapse status in the provider record before coding.