ICD-10 Code C81.49 – Lymphocyte-rich Hodgkin lymphoma, extranodal and solid organ sites (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C81.49 – Lymphocyte-rich Hodgkin lymphoma, extranodal and solid organ sites
What it is
C81.49 identifies lymphocyte-rich Hodgkin lymphoma arising in extranodal or solid organ sites. Use it when the record specifies this lymphoma subtype and the involved site is outside lymph nodes.
Clinical signs
Clinical features vary; refer to documentation. Typical Hodgkin lymphoma findings may include enlarging mass, lymphadenopathy, constitutional symptoms, or biopsy-confirmed lymphocyte-rich histology at an extranodal site.
When to use this code
Use this code when the provider documents lymphocyte-rich Hodgkin lymphoma in an extranodal or solid organ location, such as an organ mass with pathology confirming the subtype. You should code from the final documented diagnosis, not from suspected disease alone. Check documentation if the site or histology is unclear.
Do not use for
Do not use it for other Hodgkin lymphoma subtypes, unspecified Hodgkin lymphoma, or nodal-only disease. If the record does not confirm extranodal or solid organ involvement, choose the more accurate documented code.
Coding tip
Verify both the histologic subtype and the anatomic site before assigning C81.49.