ICD-10 Code C81.48 – Lymphocyte-rich Hodgkin lymphoma, lymph nodes of multiple sites (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C81.48 – Lymphocyte-rich Hodgkin lymphoma, lymph nodes of multiple sites
What it is
C81.48 identifies lymphocyte-rich Hodgkin lymphoma involving lymph nodes at multiple sites. Use it when documentation specifies this Hodgkin lymphoma subtype and indicates more than one nodal region is affected.
Clinical signs
Patients may present with painless lymph node enlargement, often in more than one area. Clinical features vary; refer to documentation for pathology confirmation of the lymphocyte-rich subtype.
When to use this code
Use this code when the provider documents lymphocyte-rich Hodgkin lymphoma and notes lymph nodes of multiple sites. It is appropriate for confirmed diagnosis, staging workup, or follow-up visits tied to this specific lymphoma. If the site or subtype is unclear, check documentation.
Do not use for
Do not use this code for other Hodgkin lymphoma subtypes or for unspecified nodal involvement. If the record does not confirm multiple sites or the lymphocyte-rich variant, check documentation.
Coding tip
Match both the histologic subtype and the anatomic extent in the record before assigning C81.48.