ICD-10 Code C81.29 – Mixed cellularity Hodgkin lymphoma, extranodal and solid organ sites (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C81.29 – Mixed cellularity Hodgkin lymphoma, extranodal and solid organ sites
What it is
C81.29 identifies mixed cellularity Hodgkin lymphoma involving extranodal or solid organ sites. Use it when documentation specifies this Hodgkin lymphoma subtype and indicates spread beyond lymph nodes.
Clinical signs
Clinical features vary; refer to documentation. Commonly reported findings in Hodgkin lymphoma include enlarged lymph nodes, systemic “B” symptoms, and evidence of involvement outside the lymphatic system.
When to use this code
Use C81.29 when the provider documents mixed cellularity Hodgkin lymphoma with extranodal or solid organ involvement, such as disease in an organ or tissue outside lymph nodes. Code it from the final documented diagnosis, not from suspicion alone.
Do not use for
Do not use this code for Hodgkin lymphoma confined to lymph nodes or when the subtype is not documented. Check documentation if the record only says lymphoma, Hodgkin disease, or metastatic disease without this specific diagnosis.
Coding tip
Verify both the subtype and the extranodal/solid organ site in the provider note before assigning C81.29.