ICD-10 Code C81.10 – Nodular sclerosis Hodgkin lymphoma, unspecified site (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C81.10 – Nodular sclerosis Hodgkin lymphoma, unspecified site
What it is
C81.10 identifies nodular sclerosis Hodgkin lymphoma when the site is not specified in the record. Use it for this classic Hodgkin lymphoma subtype when documentation names the subtype but does not identify a more specific anatomic site.
Clinical signs
Clinical features vary; refer to documentation. Commonly reported findings include painless lymph node enlargement, often in the neck or mediastinum, and sometimes B symptoms such as fever, night sweats, or weight loss.
When to use this code
Use this code when the provider documents nodular sclerosis Hodgkin lymphoma and does not specify a site. It also fits when the note confirms the subtype but only gives a general lymphoma diagnosis without a more precise location. If the record later identifies a site, code that more specific option instead.
Do not use for
Do not use C81.10 for other Hodgkin lymphoma subtypes or for non-Hodgkin lymphoma. If documentation specifies a particular nodal or extranodal site, check documentation and select the more specific code.
Coding tip
Code the subtype exactly as documented, and query for site specificity when the record is incomplete.