ICD-10 Code A51.46 – Secondary syphilitic osteopathy (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code A51.46 – Secondary syphilitic osteopathy
What it is
A51.46 identifies bone disease caused by secondary syphilis. Use it when documentation links syphilitic infection to osteopathy affecting the skeleton.
Clinical signs
Clinical features vary; refer to documentation. You may see bone pain, tenderness, or imaging evidence of skeletal involvement in the setting of secondary syphilis.
When to use this code
Use this code when the provider documents secondary syphilis with osteopathic or bony involvement. It applies when the bone condition is attributed to the syphilitic infection, not to trauma or another cause. Check documentation if the record only states syphilis without skeletal disease.
Do not use for
Do not use A51.46 for primary bone infections, nonsyphilitic osteitis, or unspecified syphilis without bone involvement. Check documentation when the site or stage is unclear.
Coding tip
Confirm both the syphilis stage and the documented skeletal involvement before assigning A51.46.