ICD-10 Code A51.45 – Secondary syphilitic hepatitis (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code A51.45 – Secondary syphilitic hepatitis
What it is
This code identifies liver inflammation caused by secondary syphilis. Use it when the record links hepatitis to active secondary syphilis rather than another liver disease.
Clinical signs
Clinical features vary; refer to documentation. Records may describe hepatitis with concurrent secondary syphilis findings, such as rash, mucous patches, or generalized lymphadenopathy.
When to use this code
Use A51.45 when the provider documents secondary syphilitic hepatitis or clearly states that syphilis is the cause of the hepatitis. It may also apply when hepatitis is part of a documented secondary syphilis presentation. Check documentation if the liver involvement is suspected but not confirmed.
Do not use for
Do not use this code for hepatitis from other infections, alcohol, drugs, or autoimmune disease. Do not assign it when syphilis is present without documented hepatic involvement.
Coding tip
Code the syphilis manifestation only when the provider links the hepatitis to secondary syphilis in the note.