ICD-10 Code G92.03 – Immune effector cell-associated neurotoxicity syndrome, grade 3 (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code G92.03 – Immune effector cell-associated neurotoxicity syndrome, grade 3
What it is
G92.03 identifies grade 3 immune effector cell-associated neurotoxicity syndrome, a severe neurologic toxicity that can occur after immune effector cell therapy. Use it when documentation specifically states grade 3 ICANS.
Clinical signs
Clinical features vary; refer to documentation. Grade 3 ICANS is generally associated with marked neurologic impairment, such as significant confusion, reduced responsiveness, or severe language disturbance.
When to use this code
Use this code when the provider documents immune effector cell-associated neurotoxicity syndrome and clearly assigns grade 3 severity. It may appear in CAR-T or other immune effector cell therapy records. If the grade is not stated, check documentation before coding.
Do not use for
Do not use G92.03 for nonspecific encephalopathy, delirium, or neurologic symptoms without a documented ICANS diagnosis. Do not assign it when the toxicity grade is another level or is unspecified.
Coding tip
Code from the provider’s documented ICANS grade, and query if the severity level is missing or unclear.