ICD-10 Code E76.8 – Other disorders of glucosaminoglycan metabolism (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E76.8 – Other disorders of glucosaminoglycan metabolism
What it is
E76.8 identifies inherited disorders that affect the breakdown or handling of glycosaminoglycans, a group of complex sugars in connective tissues. Use it when the chart documents a specific mucopolysaccharide or related metabolic disorder not captured by a more specific code.
Clinical signs
Clinical features vary; refer to documentation. Commonly reported findings in these disorders may include skeletal abnormalities, coarse facial features, organ enlargement, developmental delay, or progressive functional decline.
When to use this code
Use E76.8 when the provider diagnoses an other specified disorder of glycosaminoglycan metabolism and the record does not support a more specific ICD-10-CM code. It is appropriate for confirmed metabolic conditions, not for screening or family history alone. Check documentation if the exact subtype is unclear.
Do not use for
Do not use this code for mucopolysaccharidosis types with their own specific ICD-10-CM codes. Also avoid it when the note only mentions suspected disease, abnormal testing, or nonspecific developmental concerns without a documented metabolic diagnosis.
Coding tip
Code the most specific documented subtype first; use E76.8 only when the provider states an unspecified or other glycosaminoglycan metabolism disorder.