ICD-10 Code E72.52 – Trimethylaminuria (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E72.52 – Trimethylaminuria
What it is
Trimethylaminuria is a metabolic disorder in which the body cannot properly break down trimethylamine. This leads to a characteristic fish-like body odor that can be persistent or intermittent.
Clinical signs
Typical findings include unpleasant odor from breath, sweat, urine, or body fluids, often without other physical abnormalities. Clinical features vary; refer to documentation.
When to use this code
Use E72.52 when the provider documents trimethylaminuria, fish odor syndrome, or a confirmed disorder of trimethylamine metabolism. Apply it when the diagnosis is established and the odor is attributed to this condition. Check documentation if the chart only mentions odor without a diagnosis.
Do not use for
Do not use this code for temporary body odor from hygiene issues, infection, or dietary causes alone. It is also not appropriate when trimethylaminuria is only suspected and not documented as the diagnosis.
Coding tip
Code the condition only when the clinician clearly links the odor complaint to trimethylaminuria.