ICD-10 Code E31 – Polyglandular Dysfunction (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E31 – Polyglandular dysfunction
What it is
E31 identifies polyglandular dysfunction, a disorder involving impaired function of more than one endocrine gland. Use it when the record documents a polyglandular syndrome or multiple gland failure without a more specific code.
Clinical signs
Clinical features vary; refer to documentation. Common findings may include signs of endocrine insufficiency affecting several glands, such as autoimmune-related hormone deficiency, but you should code only what is documented.
When to use this code
Use E31 when the clinician states polyglandular dysfunction, polyglandular autoimmune syndrome, or a similar diagnosis and no more specific subtype is documented. It also fits when multiple endocrine glands are affected and the note does not support a separate, more precise code.
If the record names a specific syndrome or associated endocrine disorder, code that documented condition instead of relying on this broad category. Check documentation when the chart only lists abnormal endocrine tests or suspected gland dysfunction.
Do not use for
Do not use this code for isolated single-gland disorders or for nonspecific endocrine symptoms without a documented diagnosis. Avoid it when a more specific endocrine or autoimmune code is clearly supported.
Coding tip
Review the provider’s exact syndrome name and gland involvement before assigning E31, because specificity may change the correct code.