ICD-10 Code E31.1 – Polyglandular hyperfunction (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E31.1 – Polyglandular hyperfunction
What it is
E31.1 identifies polyglandular hyperfunction, a disorder involving overactivity of more than one endocrine gland. Use it when documentation states this specific condition or a polyglandular endocrine overfunction syndrome.
Clinical signs
Clinical features vary; refer to documentation. Findings may reflect excess hormone activity from multiple glands, with signs depending on which glands are involved and the underlying endocrine disorder.
When to use this code
Use E31.1 when the provider documents polyglandular hyperfunction or an equivalent diagnosis. It may also fit when the record clearly describes multiple endocrine glands functioning excessively without a more specific coded condition.
If the note identifies the exact endocrine disorder, code that more specific diagnosis instead. Check documentation when the chart only mentions endocrine abnormalities without confirming polyglandular hyperfunction.
Do not use for
Do not use this code for isolated single-gland hyperfunction or for hypofunction disorders. If the documentation supports a different endocrine syndrome or a more specific diagnosis, code that condition instead.
Coding tip
Query the provider if the record mentions multiple endocrine abnormalities but does not explicitly confirm polyglandular hyperfunction.